By Tony Ganino Bach Science Info Tech.
Methods Of Sterilising Humans Of All Pathogen Related Disease, Cancer, Neural Surgery
Proposal for the development of a machine that scans the body at a cellular and sub-cellular level and is able to identify and destroy. A type of scan similar to Magnetic Resonance Imaging (MRI) machine where particular cells, virii, bacteria and other artefacts are searched for and when found destroyed by a gamma radioactive cross section destroying the target. The procedure is programmed into the machine and done in real time. For example the operator may tell the machine to search for the Ebola virus or another specific signature and the patient placed into the machine and the machine will scan, identify and destroy as detected. Artificial intelligence algorithms will be used to identify what the voxel target is and what the voxel target builds into and determine if it should be irradiated and grid the body as to track a vibrating or moving target. The radio based nano weapon is comprised of many harmless level of gamma rays that reach massive intensity when they cross, the picture right illustrates how 2 harmless rays have a higher intensity at the cross-section, gamma rays penetrate the body without creating a destructive path, the destruction only occurs at the point the multiple strike cross. The machine can destroy a variety of artefacts in the body non-invasive at a three-dimensional point. The radio active strike is the diameter of a virus or cell. The aim is get successfully underneath it all but a machine like the one described poses technological and developmental challenges.
As well has having many uses from cancer, aids, pathogens, neural brain surgery, routinely clearing clots and damaged cells and other non-invasive surgery the machine will add 30 years onto the average human lifespan. The machine must strike with perfect precision, the patient should not feel any effects or side effects from the procedure.
The developmental cycle of such as machine can be progressive beginning with perfecting non-evasive stone removal version 1.0 of the machine and versioning to smaller and smaller artefacts. Even today's level or MRI machine technology along with examples such as Google's deep mind can begin to tackle a range of health problems.
If was determined to zap a human at the level of radiation required would kill the subject so the radiation must be cleaned up, more directed as suggested in the current version.
Imagine an irradiation method similar to the irradiation of fruit but safe for humans, a kill all switch against all pathogens.
In the same way we use radiation to sterilize fruit we can sterilize humans.
Such a machine would look similar to an MRI machine, where the candidate would be immersed in and zapped with a cobalt based gamma radiator to the point that all pathogens die. The dose should be enough to kill the pathogens but not enough to kill the human being or cells.
With more research the machines safety and effectiveness can be improved.
The machine could also be used to test if an unknown or mystery illness is based on a pathogen.
In a case of a local infection the method can be used to sterilize only the local area.
The success of this machine and method would issue in a new era in disease control for humans with no pathogen able to be effective in creating disease ever again.
The Food and Drug Administration has approved irradiation of meat and poultry and allows its use for a variety of other foods, including fresh fruits and vegetables, and spices. The agency determined that the process is safe and effective in decreasing or eliminating harmful bacteria. Irradiation also reduces spoilage bacteria, insects and parasites, and in certain fruits and vegetables it inhibits sprouting and delays ripening.
The effects of irradiation on the food and on animals and people eating irradiated food have been studied extensively for more than 40 years.
Kevin M. Keener Department of Food Science, NCSU states…
Irradiation is the deliberate process of exposing an item to certain types of radiation energy to bring about desirable changes. Ionizing radiation is radiant energy that has the ability to break chemical bonds. There are three types of ionizing radiation that can potentially be used in food irradiation: electron beams (machine generated), X-rays - (machine generated), and gamma rays (occur naturally from radioactive decay of Cesium 137 or Cobalt 60). Cobalt-60 is most commonly used for food irradiation, though electron beam is finding increasing application.
Currently, there are a number of non-food related products being irradiated (cosmetics, wine corks, hospital supplies, medical products, packaging materials) mostly to achieve non-thermal sterilization. The radiation dose refers to the amount of these gamma rays absorbed by the product and is measured in Grays (Gy). 1 Gy = 1 Joule of absorbed energy / kg of product. Most treatment levels are on the order of 1 to 10 kGy (1 kGy = 1000 Gy).
Approved doses for meat and poultry can reduce salmonella and E. coli populations from 99.9% to 99.999%. Hundreds of studies found no health-related issues from consuming irradiated food at levels less than 10 kGy.
Ionizing radiation can also be used to produce sterile, shelf-stable products. Irradiation has been demonstrated to produce no harmful effects at levels up to and above 60kGy. At these high levels, there have been some significant vitamin losses, but the product is commercially sterile and has a shelf-life comparable to canned foods. High levels of irradiation have already been approved for foods for NASA's Space Program and for immune-compromised hospital patients.
Irradiation can be used to sterilize (eliminate all microorganisms) food products at levels above 10 kGy. In the range of 1-10 kGy it can be used to pasteurize food (eliminate a significant number of microorganisms including those of public health significance). In some products it can be used as an insect disinfestation treatment (less than 1 kGy). It can be used as a sprout inhibition technique in potatoes and onions (less than 0.5 kGy). It can delay ripening of certain fruits (less than 0.3 kGy) and eliminate trichinosis in pork (less than 1.0 kGy).
There are three stages of radiation toxicity when total body exposure is involved.
1. Hematopoetic syndrome: 0.7 to 10 Gy. The survival rate of patients with this syndrome decreases with increasing dose. The primary cause of death is the destruction of the bone marrow, resulting in infection and hemorrhage.
2. Gastrointestinal Syndrome: 10 to 50 Gy: Survival is extremely unlikely with this syndrome. Destructive and irreparable changes in the GI tract and bone marrow usually cause infection, dehydration, and electrolyte imbalance. Death usually occurs within 2 weeks.
3. Cardiovascular/ Central Nervous System Syndrome: >50 Gy Death occurs within 3 days. Death likely is due to collapse of the circulatory system as well as increased pressure in the confining cranial vault as the result of increased fluid content caused by edema, vasculitis, and meningitis.
Normal background radiation is approximately equivalent to 0.0001 Gray.
Also these doses are total body. If just a small part of your body got that high of a dose you wouldn't experience those symptoms. And the dose has to be all at once. If, for example, like cancer treatment, it's split up among several treatments it doesn't have the same affect.
Could work but we need to improve it, make it cleaner! maybe moving to detect and destroy by localizing higher amounts of radiation could be used, also their may be wavelength difference in effectiveness to size.
(Nanowerk News) The National Institutes of Health is challenging science innovators to compete for prizes totaling up to $500,000, by developing new ways to track the health status of a single cell in complex tissue over time. The NIH Follow that Cell Challenge seeks tools that would, for example, monitor a cell in the process of becoming cancerous, detect changes due to a disease-causing virus, or track how a cell responds to treatment.
“Advances in cellular analysis promise earlier diagnosis and improved therapies for diseases, from cancer to Alzheimer’s,” said James Anderson, M.D., Ph.D., director of NIH’s Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI). “These prizes will also help to stimulate new businesses and economic growth in our biomedical communities.”
The challenge aims to generate creative ideas and methods for following and predicting a single cell’s behavior and function over time in a complex multicellular environment – preferably using multiple integrated measures to detect its changing state.
The challenge is issued under America COMPETES, by the National Institute of Mental Health (NIMH) and National Institute of Biomedical Imaging and Bioengineering (NIBIB), on behalf of the NIH Common Fund’s Single Cell Analysis Program (SCAP), part of DPCPSI.
“All cells of a particular type are not identical,” explained Anderson. “An individual cell may become very different, affecting the health and function of its entire population. Today’s tools provide mostly snapshots of single cells, not the movie of changes over time that we need to understand cell states and transitions from one state to another.”
Although several grant-supported studies exploring these issues are underway, SCAP sought to stimulate efforts beyond academia among a more diverse community than researchers who typically apply for NIH grants. These include innovators and problem solvers from U.S. industry research and development and even from fields outside of biomedicine.
Phase 1 of the challenge, which begins today, seeks theoretical, written solutions, due by Dec. 15, 2014. Submissions will be screened by panels of outside and NIH staff experts prior to review by a three-judge panel consisting of the NIMH, NIBIB, and DPCPSI directors, who will award up to six prizes totaling $100,000, to be announced March 16, 2015.
Phase 1 winners and runners-up will be eligible to participate in Phase 2, a “Reduction to Practice” to provide proof of concept data related to their Phase 1 entries. These submissions will be due March 30, 2017. One or two winning solutions will receive prizes totaling $400,000, to be announced July 31, 2017. Details of the criteria by which entries will be evaluated were published in the Federal Register Aug. 11, 2014. A registration link for the Challenge is available on the SCAP Challenge page and on the Follow That Cell website maintained by InnoCentive, Inc., which is hosting and marketing the challenge under contract with NIH. While only citizens or permanent residents of the United States are eligible to compete individually as solvers, non-citizens may participate as a member of a team.
“We believe that combining the immense brainpower of scientists, engineers and innovators will propel the development of the next generation of single cell analysis, galvanizing this field,” said Anderson.
Source: National Institutes of Health
Instead of a radio ray to kill the virus, a sonic weapon may be effective.
Scientists may one day be able to destroy viruses in the same way that opera singers presumably shatter wine glasses. New research mathematically determined the frequencies at which simple viruses could be shaken to death.
“The capsid of a virus is something like the shell of a turtle,” said physicist Otto Sankey of Arizona State University. “If the shell can be compromised [by mechanical vibrations], the virus can be inactivated.”
Recent experimental evidence has shown that laser pulses tuned to the right frequency can kill certain viruses. However, locating these so-called resonant frequencies is a bit of trial and error.
“Experiments must just try a wide variety of conditions and hope that conditions are found that can lead to success,” Sankey told LiveScience.
To expedite this search, Sankey and his student Eric Dykeman have developed a way to calculate the vibrational motion of every atom in a virus shell. From this, they can determine the lowest resonant frequencies.
As an example of their technique, the team modeled the satellite tobacco necrosis virus and found this small virus resonates strongly around 60 Gigahertz (where one Gigahertz is a billion cycles per second), as reported in the Jan. 14 issue of Physical Review Letters.
A virus' death knell
All objects have resonant frequencies at which they naturally oscillate. Pluck a guitar string and it will vibrate at a resonant frequency.
But resonating can get out of control. A famous example is the Tacoma Narrows Bridge, which warped and finally collapsed in 1940 due to a wind that rocked the bridge back and forth at one of its resonant frequencies.
Viruses are susceptible to the same kind of mechanical excitation. An experimental group led by K. T. Tsen from Arizona State University have recently shown that pulses of laser light can induce destructive vibrations in virus shells.
“The idea is that the time that the pulse is on is about a quarter of a period of a vibration,” Sankey said. “Like pushing a child on a swing from rest, one impulsive push gets the virus shaking.”
It is difficult to calculate what sort of push will kill a virus, since there can be millions of atoms in its shell structure. A direct computation of each atom's movements would take several hundred thousand Gigabytes of computer memory, Sankey explained.
He and Dykeman have found a method to calculate the resonant frequencies with much less memory.
The team plans to use their technique to study other, more complicated viruses. However, it is still a long way from using this to neutralize the viruses in infected people.
One challenge is that laser light cannot penetrate the skin very deeply. But Sankey imagines that a patient might be hooked up to a dialysis-like machine that cycles blood through a tube where it can be hit with a laser. Or perhaps, ultrasound can be used instead of lasers.
These treatments would presumably be safer for patients than many antiviral drugs that can have terrible side-effects. Normal cells should not be affected by the virus-killing lasers or sound waves because they have resonant frequencies much lower than those of viruses, Sankey said.
Moreover, it is unlikely that viruses will develop resistance to mechanical shaking, as they do to drugs.
“This is such a new field, and there are so few experiments, that the science has not yet had sufficient time to prove itself,” Sankey said. “We remain hopeful but remain skeptical at the same time.”
Where blood is a vehicle for pathogens, an blood outlet can be introduced where by the blood passes out of the body and into a sterilization machine before being pumped back into the patient, with the effect of interrupting the blood stream as a road way to further infection. Once a virus replicates it punches a hole in the cell and its offspring travel through the blood stream and the process repeats at this point it should be caught in the sterilization machine and not be able to reinfect.
The machine that sits outside the body, can either heat treat the blood beyond 105°C before injection, it may also require a small pump to aid the heart. Alternate blood that has already been sterilised be introduced.
This will also have the effect of keeping white blood cell count and blood nutrients at an optimum level and the patient feeling stronger through the process.
The amount of blood processed must be large enough to be of effect. Their may or may not be a junction point where intercept is most optimal.
Other means were to alocoholizing blood, or artificial spleen, controlling virii with magnets, as with the next article.
AFP September 15, 2014 9:26AM
SCIENTISTS say they have invented a device that uses a magnet to extract bacteria, fungi and toxins from blood, potentially throwing a lifeline to patients with sepsis and other infections.
The external gadget — tested so far in rats but not yet humans — could be adapted one day for stripping Ebola and other viruses from blood, they hoped.
Acting rather like a spleen, the invention uses magnetic nanobeads coated with a genetically-engineered human blood protein called MBL.
The MBL binds to pathogens and toxins, which can then be “pulled out” with a magnet, the developers wrote in the journal Nature Medicine.
The “bio-spleen” was developed to treat sepsis, or blood infection, which affects 18 million people in the world every year, with a 30-50 per cent mortality rate.
The microbes that cause it are often resistant to antibiotics, and spread fast.
If the invention is shown to be safe for humans, “patients could be treated with our bio-spleen and this will physically clean up their blood, rapidly removing a wide spectrum of live pathogens as well as dead fragments and toxins from the blood,” study co-author Donald Ingber told AFP on Sunday.
The cleansed blood is then returned to the circulatory system. “This treatment could be carried out even before the pathogen has been formally identified and the optimal antibiotic treatment has been chosen,” said Ingber, of Harvard University, Massachusetts.
The MBL protein is known to bind to the Ebola virus “and so it potentially might be useful for treatment of these patients,” said Ingber in an email exchange.
“We potentially could treat patients with this bio-spleen during the most infectious, viraemic phase of the disease and reduce the amount of virus in their blood.” MBL has also been reported to bind to the Marburg and HIV viruses.
In live rats infected with the notorious bugs Staphylococcus aureus or Escherichia coli, the device removed 90 per cent of bacteria from the blood, said the study.
“When we injected rats with a lethal dose of LPS endotoxin (a bacteria type) … we found that we could significantly improve animal survival” with the bio-spleen, it said.
Tests with human blood in the lab also showed the bio-spleen cleaned out multiple species of bacteria, fungi and toxins.
Years of testing in larger animals and then in humans lie ahead before the bio-spleen can be approved, Ingber cautioned.