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 ====== Regenerative Medicine, Anti-Aging, Immortality ====== ====== Regenerative Medicine, Anti-Aging, Immortality ======
  
-On the subject of immortality. I have decided to go public as it seems to have stalled againHang on, I have little choice as I am out of the loop, the Illuminati'​s offer to reveal the secret to immorality comes with one condition, they could tell but they would have to kill me but seriously, charlatans and frauds occupy the space be it Harvard grape juice or the latest miracle nootropic, they have no human studies showing efficacy and likely not add a single day to life, like eBay turbo fans that claim 500% more horsepower they in fact hinder ​the horsepower. The latest answer to the French paradox is not "​150,​000,​000 glasses of wine (sic)"​. Two human trials of Nicotinamide Riboside (N.R) and Resveratrol concluded "The study found no clinical benefit to supplementation"​ Like many multi vitamins and other supplements it is [[science:​does_not_pass_through_the_small_intestine|rejected during the digestion process]] and does not pass into the bloodstream, a caution is the organs in charge of removing toxins can become damaged by abuse, over dose and over use of these tablets. Resveratrol is destroyed by sulfuric ​acid of the stomach and never enters the bloodstream,​ they know so but that does not stop them selling the rubbish. Every so often a new fad supplement comes about promising slow aging benefits like CoQ10, PQQ, Omega 3 but they soon fade away. Wrinkle creams we all know none are effective against wrinkles. Watch out for people who focus on some minor detail, aging is bigger than one drug, supplement or a special morning ritual. ​Buzzwords like anti-oxidants,​ anti-inflammatory or anti-aging, please ​this page is not about a fad lifestyle religion. Get real, move on... +On the subject of immortality. I have decided to go public as it seems to have stalled againHang on, I have little choice as I am out of the loop, the Illuminati'​s offer to reveal the secret to immorality comes with one condition, they could tellbut they would have to kill me. But seriously, charlatans and frauds occupy the space be it Harvard grape juice or the latest miracle nootropic, they rarely ​have any studies showing efficacy and likely not add a single day to life, like eBay turbo fans that claim 500% more horsepower they in fact hinder. The latest answer to the French paradox is not "​150,​000,​000 glasses of wine (sic)"​. Two human trials of Nicotinamide Riboside (N.R) and Resveratrol concluded "The study found no clinical benefit to supplementation"​ Like many multi vitamins and other supplements it is [[science:​does_not_pass_through_the_small_intestine|rejected during the digestion process]] and does not pass into the bloodstream ​and when they get caught up in the digestive system they instead cause organ damage. Resveratrol is destroyed by sulphuric ​acid of the stomach and never enters the bloodstream,​ they know so but that does not stop them selling the rubbish. Wrinkle creams have been ineffective against wrinkles but that does not stop them. Every so often a new fad supplement comes about promising slow aging benefits like CoQ10, PQQ, Omega 3 or a fruit, ​but they soon fade away. Watch out for people who focus on some minor detail, aging is bigger than one drug, supplement or a special morning ritual. ​I will try to keep the false positives out of this article. Get real, move on... 
  
 {{ ::​1-s2.0-s0092867413006454-gr1.jpg?​direct&​200|US vs Europe Pillars Of Aging}} {{ ::​1-s2.0-s0092867413006454-gr1.jpg?​direct&​200|US vs Europe Pillars Of Aging}}
 {{ ::​the-seven-pillars-of-aging.png?​direct&​200|US vs Europe Pillars Of Aging}} {{ ::​the-seven-pillars-of-aging.png?​direct&​200|US vs Europe Pillars Of Aging}}
-Getting old? What is getting old like? I do not have the same energy levels I did when I was young and their seems to be no way of endowing the body with energy. Food does not boost the energy, a good night sleep seems to be the only practice that improves energy levels modestly. The body seems sluggish, slow and limited to perform, more aches. The body differs in appearance from a young person and fat is impossible to remove. We may have all seen an end of life boxer step into the ring with a rising force and get beaten badly, yet that same boxer was unbeatable in his younger years. ​One way to describe is imagine a new 12v battery giving out 13.5v for a long period versus and old battery that maxes out at 11.5v and only for a short time. It can still perform all the functions of the new battery but at a reduced level of speed, power and durationWe want to get the battery back to holding 13.5v with its long and fast performance but their is none to turn the old battery back into a new batteryThe battery continues to degrade and finally ceases to functionNo nootropic, fruit juice will restore that battery function. Aging has many historical, artistic narratives such as the fountain of youth depicted in the movie cocoon where evil elderly humans drain the rejuvenating pool and kill the ancient cocooned aliens the pool was made to rejuvenate and so on, some Greek who was granted immortality on condition he could never have sex again, and so he decided to die (I just made that up but their is always one of those). Right: US 7 Pillars of Aging vs. Europe Pillars of Aging. Their are theories as to why aging occurs with two predominant theories of aging. Aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development. This regulation would depend on changes in gene expression that affect the systems responsible for maintenance,​ repair and defence responses and second theory are the damage or error theories emphasize environmental assaults to living organisms that induce cumulative damage at various levels as the cause of aging and eventually critical damage. ​As aging is complex both theories ​might collaberate ​to aging and death. Most people do not want to die but no one lives forever, natures 100% perfect strike rate, their is always an exception to the rule? no exceptions. Those that accept such become more mature and more human, mortal and weak+Getting old? What is getting old like? I do not have the same energy levels I did when I was young and their seems to be no way of endowing the body with energy. Food does not boost energy, a good night sleep seems to be the only practice that improves energy levels modestly. The body seems sluggish, slow and limited to perform, more aches. The body differs in appearance from a young person and fat is impossible to remove. We may have all seen an end of life boxer step into the ring with a rising force and get beaten badly, yet that same boxer was unbeatable in his younger years. ​Read the [[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC3836174/​|hallmarks o aging]]. Aging has many historical, artistic narratives such as the fountain of youth depicted in the movie cocoon where evil elderly humans drain the rejuvenating pool and kill the ancient cocooned aliens the pool was made to rejuvenate and so on, some Greek who was granted immortality on condition he could never have sex again, and so he decided to die (I made that up but their is always one of those) ​and many more. Right: US 7 Pillars of Aging vs. Europe Pillars of Aging. Their are theories as to why aging occurs with two predominant theories of aging. Aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development. This regulation would depend on changes in gene expression that affect the systems responsible for maintenance,​ repair and defence responses and second theory are the damage or error theories emphasize environmental assaults to living organisms that induce cumulative damage at various levels as the cause of aging and eventually critical damage. ​Aging is complex ​but both theories ​are leading ​to genetics ​and epigenetics. Most people do not want to die but no one lives forever, natures 100% perfect strike rate, their is always an exception to the rule? no exceptions.
  
 Exception, in nature their is an example of immortality. Turritopsis dohrnii, the immortal jellyfish is able to revert completely to sexually immaturity, colonial stage after having reached sexual maturity as a solitary individual and theoretically,​ this process can go on indefinitely,​ effectively rendering the jellyfish biologically immortal. The Hyra and the Salamander have amazing regeneration ability, cut off its hand and it grows back. Lifespans; Arctica islandica and Ocean Quahog, shell fish both 500 years, Greenland shark 270 years, Bowhead Whales and Koi 200 years, ​ Galapagos Giant Tortoise 150 years (all the above live in the ocean) then their is a Tuataras a reptile 150 years, Elephants 70 years and Humans. The shortest lived animals, Gastrotrichs a marine microorganism 3 days, Drone Ants 3 weeks, Houseflies 4 weeks, House mouse 1 year, Chameleon 1 year, Guinea pigs 4 years, Domestic rabbits 8-12 years. Different animals have different lifespans and may suggest that lifespan is hardwired. Exception, in nature their is an example of immortality. Turritopsis dohrnii, the immortal jellyfish is able to revert completely to sexually immaturity, colonial stage after having reached sexual maturity as a solitary individual and theoretically,​ this process can go on indefinitely,​ effectively rendering the jellyfish biologically immortal. The Hyra and the Salamander have amazing regeneration ability, cut off its hand and it grows back. Lifespans; Arctica islandica and Ocean Quahog, shell fish both 500 years, Greenland shark 270 years, Bowhead Whales and Koi 200 years, ​ Galapagos Giant Tortoise 150 years (all the above live in the ocean) then their is a Tuataras a reptile 150 years, Elephants 70 years and Humans. The shortest lived animals, Gastrotrichs a marine microorganism 3 days, Drone Ants 3 weeks, Houseflies 4 weeks, House mouse 1 year, Chameleon 1 year, Guinea pigs 4 years, Domestic rabbits 8-12 years. Different animals have different lifespans and may suggest that lifespan is hardwired.
  
-General health, the whole goal is staying pre-clinical for as long possible by healthy practices. ​The longest living people and possibly the healthiest tend to live around islands namely Sardinia, Okinawa and Santorino. The water purifies the air and benefits both lungs and body. The water is high quality and the clean air and water means the food is better quality all of which lead to a longer life. Wealthy people also tend to live longer due to better conditions. In contrast, the west is hell bent on contaminating its environment with exhausts and chemicals, the air is not clean, neither is the water and the food is not fit for human consumption and people breathe smoke into their lungs along with many other disastrous practices. Clean environments that promote health aid in longer life and health span. Health and life span has developed using evolution and evolution explains many of the mechanisms we use to explain why some activity might be healthy or unhealthy. Learning to live a healthy lifestyle, the best nutritional advice is not to eat at all or fasting, the body works on air and water and very much less on food. Do cardio and weight training, secure good quality air and water and many other practices such living close to the ocean, getting some sun minus the U.V, walking barefoot on the sand, sleeping practices buy the highest quality mattress you can afford and so on. If one cannot add days to life, then optimize lifestyle through how we use our time and how we treat the body. Some people limit their sleep to have more time, move relative to climate to gain more usable days and so on. Do not discount the placebo effect as it is no small or insignificant statistical aberration, estimates of the placebo cure rate range from a low of 15 percent to a high of 72 percent. The longer the period of treatment and the larger the number of physician visits, the greater the placebo effect. Try to activate the placebo effect in your lifestyle. However, their are many practices that people push but in reality will not stop aging, the bodies intent to age requires more powerful action.+The longest living people and possibly the healthiest tend to live around islands namely Sardinia, Okinawa and Santorino. The water purifies the air and benefits both lungs and body. The water is high quality and the clean air and water means the food is better quality all of which lead to a longer life. Wealthy people also tend to live longer due to better conditions. In contrast, the west is hell bent on contaminating its environment with exhausts and chemicals, the air is not clean, neither is the water and the food is not fit for human consumption and people breathe smoke into their lungs along with many other disastrous practices. Clean environments that promote healthaid in longer life and health span. Health and life span has developed using evolution and evolution explains many of the mechanisms we use to explain why some activity might be healthy or unhealthy. Learning to live a healthy lifestyle, the best nutritional advice is not to eat at all or fasting, the body works on air and water and very much less on food. Do cardio and weight training, secure good quality air and water and many other practices such living close to the ocean, getting some sun minus the U.V, walking barefoot on the sand, sleeping practices buy the highest quality mattress you can afford and so on. If one cannot add days to life, then optimize lifestyle through how we use our time and how we treat the body. Some people limit their sleep to have more time, move relative to climate to gain more usable days and so on. Do not discount the placebo effect as it is no small or insignificant statistical aberration, estimates of the placebo cure rate range from a low of 15 percent to a high of 72 percent. The longer the period of treatment and the larger the number of physician visits, the greater the placebo effect. Try to activate the placebo effect in your lifestyle. However, their are many practices that people push but in reality will not stop aging, the bodies intent to age requires more powerful action. Think general health, the whole goal is staying pre-clinical for as long possible by healthy practices
  
-Free radicals, oxidative stress. A major theory of aging is the free radicals theory or aging. The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. A free radical is any atom or molecule that has a single unpaired electron in an outer shell. It is believed that over 90 diseases are related to oxidative stress. The assumption is electrons in your body come from food and can only be derived from food "​anti-oxidants"​ but that is not the reality. Electrons are everywhere! Antioxidant pills and foods have become a way to market substances that have no real health benefit instead simply walk barefoot at the park, bathe in the ocean. When you electrically earth the body, electrons pass through. The most effective way of gaining electrons is by electrically earthing the body overnight. An earthing mattress is a mattress that at one point emits electrons and at the other point Earths the body, a person sleeps on the bed overnight and during that time electrons pass through the body and into the Earth fixing oxidative stress. Spending eight hours each night should not only treat the causes of these reactive species but also supply mitochondria extra electrons for energy, i.e. supplying the body with extra electrons while also earthing the body during sleep should have a major effect on health and energy as electrons are the source of energy in the body. Earthing mattress or pads are easily sourced but adding an electron generator or emitter unproven might supercharge the therapy. The mattress simply plugs into a power outlet. The earth contains electrons and the moment you touch earth at the speed of light all the atoms in your body are neutralized. Study [[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC3265077|Earthing:​ Health Implications of Reconnecting the Human Body to the Earth'​s Surface Electrons]] (no products required)[[https://ganino.com/doco.php?a=Antioxidants Free Radicals|Antioxidants and Radicals]] \\+[[https://​ganino.com/​doco.php?​a=Antioxidants Free Radicals|Free radicals, oxidative stress]]. A major theory of aging is the free radicals theory or aging. The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. A free radical is any atom or molecule that has a single unpaired electron in an outer shell. It is believed that over 90 diseases are related to oxidative stress. The assumption is electrons in your body come from food and can only be derived from food "​anti-oxidants"​ but that is not the reality. Electrons are everywhere! Antioxidant pills and foods have become a way to market substances that have no real health benefit instead simply walk barefoot at the park, bathe in the ocean. When you electrically earth the body, electrons pass through. The most effective way of gaining electrons is by electrically earthing the body overnight. An earthing mattress is a mattress that at one point emits electrons and at the other point Earths the body, a person sleeps on the bed overnight and during that time electrons pass through the body and into the Earth fixing oxidative stress. Spending eight hours each night should not only treat the causes of these reactive species but also supply mitochondria extra electrons for energy, i.e. supplying the body with extra electrons while also earthing the body during sleep should have a major effect on health and energy as electrons are the source of energy in the body. Earthing mattress or pads are easily sourced but adding an electron generator or emitter unproven might supercharge the therapy. The mattress simply plugs into a power outlet. The earth contains electrons and the moment you touch earth at the speed of light all the atoms in your body are neutralized. Study [[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC3265077|Earthing:​ Health Implications of Reconnecting the Human Body to the Earth'​s Surface Electrons]] (no products required) ​and [[https://www.ultimatelongevity.com/earthing-grounding/​the-research.shtml?ref=56|Earthing Grounding The Scientific Research]]\\
  
 Rapamycin and Metformin, two touted drugs with the potential to increase human lifespan both target mTOR (mammalian target of rapamycin). Their are no human studies showing efficacy as of mid 2020. mTor is further divided into mTor1 and mTor2 each group separate process. mTor is a growth regulator in relation to available nutrients and when mTor growth regulation is suppressed perhaps during puberty the organism grows to its maximum regardless of available nutrients. Metformin (a diabetes drug) is believed to mimic the benefits of exercise in a pill without any exercise ;-) AMPK activation while Rapamycin (immune-suppressant drug) is believed to trigger autophagy something that occurs after fasting for 16 hours, autophagy improves cellular condition and the condition of every aspect of the cell is super important for health. Both these drugs have side effects with Rapamycin believed to be a weekly or twice a month drug with daily use being life-shortening and Metformin having no gain in people without Type 2 diabetes. Sestrins (Sesns) are groups of proteins made when a person excercises, accumulate in the muscle and so the possibility of "​eating"​ (big molecules not bioavailable) the proteins to mimic excercise. Stress-induced Sesn expression results in inhibition of the target of rapamycin complex 1 (TORC1). Rapamycin and Metformin, two touted drugs with the potential to increase human lifespan both target mTOR (mammalian target of rapamycin). Their are no human studies showing efficacy as of mid 2020. mTor is further divided into mTor1 and mTor2 each group separate process. mTor is a growth regulator in relation to available nutrients and when mTor growth regulation is suppressed perhaps during puberty the organism grows to its maximum regardless of available nutrients. Metformin (a diabetes drug) is believed to mimic the benefits of exercise in a pill without any exercise ;-) AMPK activation while Rapamycin (immune-suppressant drug) is believed to trigger autophagy something that occurs after fasting for 16 hours, autophagy improves cellular condition and the condition of every aspect of the cell is super important for health. Both these drugs have side effects with Rapamycin believed to be a weekly or twice a month drug with daily use being life-shortening and Metformin having no gain in people without Type 2 diabetes. Sestrins (Sesns) are groups of proteins made when a person excercises, accumulate in the muscle and so the possibility of "​eating"​ (big molecules not bioavailable) the proteins to mimic excercise. Stress-induced Sesn expression results in inhibition of the target of rapamycin complex 1 (TORC1).
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 Sirtiuns are a class of proteins that possess either mono-ADP-ribosyltransferase,​ or deacylase activity, including deacetylase,​ desuccinylase,​ demalonylase,​ demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaea and eukaryotes. The attempt to activate situins, promote biogenesis / homeostasis in Mitochrondria,​ responsible for giving energy to cells. Sirtuin, Sirt 1,​2,​3,​4,​5,​6,​7 are a class of proteins responsible for metabolism, cell cycle, DNA repair and rRNA transcription. Their are no known drugs that can trigger for example DNA repair. Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. Sirtiuns are a class of proteins that possess either mono-ADP-ribosyltransferase,​ or deacylase activity, including deacetylase,​ desuccinylase,​ demalonylase,​ demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaea and eukaryotes. The attempt to activate situins, promote biogenesis / homeostasis in Mitochrondria,​ responsible for giving energy to cells. Sirtuin, Sirt 1,​2,​3,​4,​5,​6,​7 are a class of proteins responsible for metabolism, cell cycle, DNA repair and rRNA transcription. Their are no known drugs that can trigger for example DNA repair. Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.
  
-Nicotinamide adenine dinucleotide,​ NAD+ a cofactor that is central to metabolism. Many proteins decrease with age and some increase, NAD+ is produced by the liver and said to decrease in production with age. Low levels of NAD+ are said to decrease sirtiun or parp activity, acetylation and lifespan. People who supplement with NAD+ or a precursor generally feel no benefit, do not appear more youthful and have a placebo effect outlook. It is said that without NAD+ you would die, what does that even mean? If I don'​t ​intake air and water would also die and does that mean I should ​breathe more air and drink more water and I become younger or age better? You are going to blow noxious gas all day out the exhaust, pollute the drinking water with all sorts of heavy metals and toxins then breathe in that polluted air and drink that water then push research into sugar pills for health reasons? ​Another important information to consider is that when people supplement the organ that normally produces that supplement loses its ability to do so. Such as people who supplement with testosterone,​ their testicles shrink as it no longer produces the hormone, supplementing with NAD+ may cause the same situation. In aged people this may cause low NAD+ levels for more than a year or more after it is stopped, their are also methylation deficiency that arise from supplementation. This leads to a very important question, why? Does it decrease with age and how is it remedied without supplementation. A much more difficult problem to solve. NAD+ fad supplementation is probably a scam. +Nicotinamide adenine dinucleotide,​ NAD+ a cofactor that is central to metabolism. Many proteins decrease with age and some increase, NAD+ is produced by the liver and said to decrease in production with age (almost every measure does with age). Low levels of NAD+ are said to decrease sirtiun or parp activity, acetylation and lifespan. People who supplement with NAD+ or a precursor generally feel no benefit, do not appear more youthful and have a placebo effect outlook. It is said that without NAD+ you would die, what does that even mean? If you removed a persons liver or blood they would also die, if you do not intake air and water you would also die, rather than breathe more air and drink more water instead ​blow noxious gas all day out the exhaust, pollute the drinking water with all sorts of heavy metals and toxins then breathe in that polluted air and drink and ignoring all that sell pills. NMN is not bioavailable and N.R does not make it past the digestive system. It is also a complex process, dumping substances into the bloodstream is too simplistic as their are myriad of domino effects. ​Another important information to consider is that when people supplement the organ that normally produces that supplement loses its ability to do so, dystrophy. Such as people who supplement with testosterone,​ their testicles shrink ​(hypogonadism) ​as it no longer produces the hormone, supplementing with NAD+ may cause the same situation. In aged people this may cause low NAD+ levels for more than a year or more after it is stopped ​secretly creating an addiction cycle, their are also methylation deficiency that arise from supplementation. This leads to a very important question, why? Does it decrease with age and how is it remedied without supplementation. A much more difficult problem to solve. NAD+ fad supplementation is probably a scam. Niacin, Vitamin B3 is a cheap yet equal substitute for expensive N.R
  
-Telomeres, their was that whole telomeres humdrum a while back. Telomeres are the strands at the end of DNA when they decrease in length aging accelerates. The body naturally produces telomerase to maintain telomeres but attempts to increase telomeres artificially using telomerase causes cancer. Danazol may or may not be able to lengthen telomeres but has many side effects but generally not a cancer causing agent. Active ingredient Cycloastragenol is a molecule isolated from various species in the genus Astragalus that is purported to have telomerase activation activity. A single in vitro study on human CD4 and CD8 T cells led to claims that cycloastragenol may activate telomerase, leading to controversial claims for its role in reducing the effects of aging. However, this product should not be taken as their are reports of liver cancer. It is believed that cancer ​is a concern for the body and billions of cells are apoptose and replaced each day to avoid cell dysfunction including cancer. Dyskeratosis congenita (DKC), also known as zinsser-engman-cole syndrome is characterized by short telomeres. Some of the manifestations resemble premature aging (similar to progeria), it might be caused by a gene mutation inhibiting telomerase production.+Telomeres ​(Blackburn, Greider), their was that whole telomeres humdrum a while back. Telomeres are the strands at the end of DNA when they decrease in length aging accelerates. The body naturally produces telomerase to maintain telomeres but attempts to increase telomeres artificially using telomerase causes cancer. If a cell has DNA damage and short telomeres, extending the telomeres and the cell divides multiplies the DNA damage which is cancer level unhealthy. Danazol may or may not be able to lengthen telomeres but has many side effects but generally not a cancer causing agent. Active ingredient Cycloastragenol is a molecule isolated from various species in the genus Astragalus that is purported to have telomerase activation activity. A single in vitro study on human CD4 and CD8 T cells led to claims that cycloastragenol may activate telomerase, leading to controversial claims for its role in reducing the effects of aging. However, this product should not be taken as their are reports of liver cancer. It is believed that in an effort to avoid cancer and other dysfunction ​billions of cells are apoptose and replaced each day. Dyskeratosis congenita (DKC), also known as zinsser-engman-cole syndrome is characterized by short telomeres. Some manifestations resemble premature aging (similar to progeria), it might be caused by a gene mutation inhibiting telomerase production. Telomeres is part of a group of aged cell morphology issues of which their are many, a protocol must be particular about the many aspect of a cell's condition prior to extending telomeres.
  
-Cdc42, when any cell in the body needs replacing it most likely will come from your own haematopoietic stem cells, as the bodies haematopoietic stem cells generation factory ages they come functional yet degraded from the beginning. Cdc42 activity regulates haematopoietic stem cell aging and rejuvenation. Department of Dermatology and Allergic Diseases, University of Ulm, 89091 Ulm, Germany. The decline in haematopoietic function seen during aging involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, and has been linked to aging of haematopoietic stem cells (HSCs). The molecular mechanisms underlying HSC aging remain unclear. In their paper they demonstrate that elevated activity of the small RhoGTPase Cdc42 in aged HSCs is causally linked to HSC aging and correlates with a loss of polarity in aged HSCs. Pharmacological inhibition of Cdc42 activity functionally rejuvenates aged HSCs, increases the percentage of polarized cells in an aged HSC population, and restores the level and spatial distribution of histone H4 lysine 16 acetylation to a status similar to that seen in young HSCs. Their data suggests a mechanistic role for Cdc42 activity in HSC biology and epigenetic regulation, and identify Cdc42 activity as a pharmacological target for ameliorating stem cell aging.+Cdc42, when any cell in the body needs replacing it most likely will come from your own haematopoietic stem cells, as the bodies haematopoietic stem cells generation factory ages they come functional yet degraded from the beginning. Cdc42 activity regulates haematopoietic stem cell aging and rejuvenation. Department of Dermatology and Allergic Diseases, University of Ulm, 89091 Ulm, Germany ​[[https://​pubmed.ncbi.nlm.nih.gov/​22560076/​|1]],​[[https://​pubmed.ncbi.nlm.nih.gov/​24141946/​|2]]. The decline in haematopoietic function seen during aging involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, and has been linked to aging of haematopoietic stem cells (HSCs). The molecular mechanisms underlying HSC aging remain unclear. In their paper they demonstrate that elevated activity of the small RhoGTPase Cdc42 in aged HSCs is causally linked to HSC aging and correlates with a loss of polarity in aged HSCs. Pharmacological inhibition of Cdc42 activity functionally rejuvenates aged HSCs, increases the percentage of polarized cells in an aged HSC population, and restores the level and spatial distribution of histone H4 lysine 16 acetylation to a status similar to that seen in young HSCs. Their data suggests a mechanistic role for Cdc42 activity in HSC biology and epigenetic regulation, and identify Cdc42 activity as a pharmacological target for ameliorating stem cell aging.
  
-Clearing senescent cells, damaged cells that stop dividing, called senescent cells, accumulate with age, and are thought to contribute to inflammation,​ tissue damage and age-related diseases. A peptide that impairs binding between the proteins FOXO4 and p53 — an interaction that normally inhibits the '​self-destruct'​ signal in senescent cells. Their are some drugs named senolytic drugs that are able to clear senescent cells allowing ​new cells can take their place. Good house keeping? ​We require more kinds of senolytics, ​against ​cancer, cancer prevention, scar tissue removal and so on. For example, if a senolytic could target detect and only destroy cells with short telomeres, ​one injection could be cancer prevention treatment or if it could detect and destroy only scar tissue it could be a scar tissue removal treatment and so on. The deleted senescent cell are replaced as part of the bodies natural process ​where the opportunity ​with for example cdc42 to replace ​with a higher quality ​cell.+Clearing senescent cells, damaged cells that stop dividing, called senescent cells, accumulate with age, and are thought to contribute to inflammation,​ tissue damage and age-related diseases. A peptide that impairs binding between the proteins FOXO4 and p53 — an interaction that normally inhibits the '​self-destruct'​ signal in senescent cells. Their are some drugs named senolytic drugs that are able to clear senescent cellsnew cells are formed in their place. Good house keeping? ​Senescent cell are said to secret senescent factors. Senescent associated secretory phenotype (SASP), the increased expression and secretion of a suite of inflammatory cytokines, chemokines, growth factors, and proteases (Coppé et al., 2010a; van Deursen, 2014). Senescent cells are believed to be a cell state for tumour suppression,​ while fine in the young body they compound aging in aging bodies. More types of senolytics ​are requiredfor cancer ​treatment, cancer prevention, scar tissue removal and so on, even pre-senolytic,​ anticipating cells that are showing first stages of damage. We also know that senescent cells occur in the brain so a synoletic the crosses the blood brain barrier. For example, if a senolytic could target detect and only destroy cells with short telomeres, ​an injection could be an effective ​cancer prevention treatment or if it could detect and destroy only scar tissue it could be a scar tissue removal treatment and so on. The deleted senescent cell are replaced as part of the bodies natural process ​either an adjacent cell divides or from bone marrow pericytes. These cells must be replaced ​with better cells and so an optimal replacement cell protocol is required. Methods; FOXO4-related peptides. FOXO4 can bind with p53 protein to induce cellular senescence. Inhibitors of different members of the bcl-2 family of anti-apototic proteins. Inhibitors of USP7 (Ubiquitin-specific processing protease 7). Article: [[https://​age-reversal.net/​dr-jerry-mixon-case-study/​|Using senolytics prior to stem cell infusion may or may not enhance the treatment]],​ [[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC5641223/​|The Clinical Potential of Senolytic Drugs]], [[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC1905691/​|Ageing,​ tumour necrosis factor-alpha (TNF-α) and atherosclerosis]]. Typical drug protocol senolytic drugs Dasatinib + Quercertin twice annually (not pills instead injections).
  
-Hypothalamus,​ the hypothalamus starts and ends puberty, initiates body changes for pregnancy and initiates ​menopause and the gland also knows how to keep time, the circadian rhythm or day/night cycle is in the hypothalamus. This small gland in the brain is believed to keep time for an organism'​s lifespan. It also exists in the most ancient part of the brain called the limbic system, circadian rhythms exists in every animal and plants. When the hypothalamus senses low oestrogen in the blood of a woman it sends a signal to the pituitary gland which in turn sends a signal to the ovaries to produce more oestrogen, in males that dope on testosterone or steroids cause dystrophy to their testicles because the hypothalamus sensing adequate levels of testosterone will not require the testicles to produce testosterone. ​It is the hypothalamus that decides if a woman is pre and post menopausal and then sets the specific regulation ​of oestrogen levels ​which suggests that gene expression ​is being regulated by lifespan time keeping mechanism in the hypothalamus. That the circadian rhythm is in the hypothalamus makes the organ highly suspicious of being in part the timer for lifespan. The master clock of the human body is called the (SCN) Suprachiasmatic nucleus consisting of 20,000 neurons, time keeping systems like these in the central nervous system are believed to be dictating the lifespan of an organism. In this case averting death is similar to attempting to avoid puberty, regardless of what you do sooner of later it is going to happen. Centenarians persons that live up to and past 100 years run in families and different animals have their specific lifespan both suggest genetic lifespan mechanism ​and that mechanism may be a group of neurons in the brain keeping time. Depending on the time parts of the genome are expressed while other parts are no longer expressed. Researchers at Albert Einstein College of Medicine conducted a study on mice. They discovered that as mice age, levels of molecules, specifically IKK-β and NF-kB, molecules that initiate inflammatory responses, increase in the brain, particularly in the hypothalamus. The concentration of the pro inflammatory cytokine ​tumor necrosis factor β also increases. The increases directly cause a decline in gonadotropin-releaseing hormone (GnRH). Mice that produced less IKK-β and NF-kB in the hypothalamus created more neurons and solved mazes more quickly, had greater muscle strength, and exhibited a 20% longer lifespan. The opposite effects were seen in mice that overproduced IKK-β and NF-kB. +Hypothalamus,​ the hypothalamus ​controls child growth phase, ​starts and ends puberty, initiates body changes for pregnancy and menopause and the gland also knows how to keep time, the circadian rhythm or day/night cycle is in the hypothalamus. This small gland in the brain is believed to keep time for an organism'​s lifespan. It exists in the most ancient part of the brain called the limbic system. When the hypothalamus senses low oestrogen in the blood of a woman it sends a signal to the pituitary gland which in turn sends a signal to the ovaries to produce more oestrogen, in males that dope on testosterone or steroids cause dystrophy to their testicles because the hypothalamus sensing adequate levels of testosterone will not require the testicles to produce testosterone. ​Puberty occurs with clockwork regularity, ​the method ​and control ​of which is unknown, perhaps it is neural clock perhaps accumulation of methylation act as a clock, telomeres are a type of cell division clock. That the circadian rhythm is in the hypothalamus makes the organ highly suspicious of being in part the timer for lifespan, such a master clock of the human body is called the (SCN) Suprachiasmatic nucleus consisting of 20,000 neurons, time keeping systems like these in the central nervous system are believed to be dictating the lifespan of an organism. In this case averting death is similar to attempting to avoid puberty, regardless of what you do sooner of later it is going to happen. Centenarians persons that live up to and past 100 years run in families and different animals have their specific lifespan both suggest genetic lifespan mechanism. Depending on the time parts of the genome are expressed while other parts are no longer expressed. The strategy of the hypothalamus is one organ has major importance to aging while other have minor importance. What happens at the important organ goes systemic and the effect cascades or it has a domino effect throughout the body. The endocrine system with the hypothalamus being number one and the pituitary gland number two. Researchers at Albert Einstein College of Medicine conducted a study on mice. They discovered that as mice age, levels of molecules, specifically IKK-β and NF-kB, molecules that initiate inflammatory responses, increase in the brain, particularly in the hypothalamus. The concentration of the pro inflammatory cytokine ​tumour ​necrosis factor β also increases. The increases directly cause a decline in gonadotropin-releaseing hormone (GnRH). Mice that produced less IKK-β and NF-kB in the hypothalamus created more neurons and solved mazes more quickly, had greater muscle strength, and exhibited a 20% longer lifespan. The opposite effects were seen in mice that overproduced IKK-β and NF-kB. Zhang G et al. Hypothalamic programming of systemic ageing involving IKK-β, NF-kB and GnRH. Nature 2013 May 9; 497:211. Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature 2013 May 9; 497:197. [[https://​www.sciencedaily.com/​releases/​2017/​07/​170726132107.htm|1]]
-Zhang G et al. Hypothalamic programming of systemic ageing involving IKK-β, NF-kB and GnRH. Nature 2013 May 9; 497:211. Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature 2013 May 9; 497:197+
  
 Trans-humanism,​ biomedical engineering,​ replacing many parts of the body with "​superior"​ mechanical prosthetics. Improving prosthetic technology has noble medical applications either way, the key is fusing bio with the mechanical. Not growing a new bio liver with stem cells, but being able to make such organs and limbs mechanically and have them perform to the same standard. Their are issues with the complexity of the human body causing the prosthetic to be always unsatisfactory. People want an arm, hand and fingers that are identical to their biological version in every way. From the effortless control of the limb to its dexterity and if it falls short ever so slightly then it fails completely. Eventually only the head will remain and then only the brain and so on. The whole head transplant, organ transplant system has to fade into history and that chapter closed. The major issue is that when a person loses an arm or a leg hospital duration is 6 months and rehabilitation takes years and also modern prosthetics are still not ideal. The advantage is that metal lasts a very long time and is simpler than the body limb, living on Mars or on the Moon becomes applicable as no oxygen is required and the materials can handle the harsh environments. How to make Voltron? Call four sexy friends "Form Voltron, activate interlock, Go Voltron Force" I prefer Mighty Morphin'​ Power Rangers. Oh, continue reading... Trans-humanism,​ biomedical engineering,​ replacing many parts of the body with "​superior"​ mechanical prosthetics. Improving prosthetic technology has noble medical applications either way, the key is fusing bio with the mechanical. Not growing a new bio liver with stem cells, but being able to make such organs and limbs mechanically and have them perform to the same standard. Their are issues with the complexity of the human body causing the prosthetic to be always unsatisfactory. People want an arm, hand and fingers that are identical to their biological version in every way. From the effortless control of the limb to its dexterity and if it falls short ever so slightly then it fails completely. Eventually only the head will remain and then only the brain and so on. The whole head transplant, organ transplant system has to fade into history and that chapter closed. The major issue is that when a person loses an arm or a leg hospital duration is 6 months and rehabilitation takes years and also modern prosthetics are still not ideal. The advantage is that metal lasts a very long time and is simpler than the body limb, living on Mars or on the Moon becomes applicable as no oxygen is required and the materials can handle the harsh environments. How to make Voltron? Call four sexy friends "Form Voltron, activate interlock, Go Voltron Force" I prefer Mighty Morphin'​ Power Rangers. Oh, continue reading...
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 {{ ::​progeria.png?​direct|}} {{ ::​progeria.png?​direct|}}
  
-The difference being male or female is said to be the instructions within the XX chromosome or the XY chromosome. The male produces both types, when the specific gene is read the instruction is a boy or a girl. Some reptiles have an environmental determinate,​ for example hot outside, a male versus cold outside, a female. This illustrates epigenetics and the powerful machine of genetics. One theory of aging is that as part of the complex machinery of evolution, the genetics is programmed ultimately to end life. At a certain age the body down regulates factors that cause the human body to decline and ultimately die. It is also believed that their is a hard genetic cut off switch ending life. Centenarians run in families (genetic cause) and some say that the genetics of the mitochondria in centenarians differs from that of a short-lived person. Progeria is an extremely rare autosomal dominant genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Progeria is one of several progeroid syndromes. Those born with progeria typically live to their mid-teens to early twenties. Progeria is caused by mutations that weaken the structure of the cell nucleus, making normal cell division difficult. The histone mark H4K20me3 is involved in Hutchinson-Gilford Progeria syndrome caused by de novo mutations that occurs in a gene that encodes lamin A. Lamin A is made but is not processed properly. This poor processing creates an abnormal nuclear morphology and disorganized heterochromatin. Patients also do not have appropriate DNA repair, and they also have increased genomic instability. Genetics is so complex that the result is hundreds if not thousands of years of well intended snake oils and years wasted on therapies of limited or inadequate success, possibly a complex situation where a result is impossible and unobtainable. Progeria is a key insight in both genetic errors and cell deformation causing health problems, suggesting that both theories of aging may be correct. Is a hormone or protein later in age produced in correct quantity but perhaps cannot exit the subtle deformity of an aged cell? The difference between a nutrient entering the cell or not is so small that perhaps the aged cell struggles to accept nutrients through its slightly deformed pores and so on. Inbreeding expressing defects in the genome that present as pathology in the body, the likelihood of health issues and early death is increased. Birth defects and DNA damage cell damage relating to nuclear radiation. See how visually the shape of nucleus tells of a problem, that is to consider in cell biology, the slender shapes, the good formations, we are talking about micron deformation here. The cell has to be perfect. These are pathologies that look like aging. When doctors talk of fatty acid build up or some other situation what they are really saying is your cells are aging, and they are not behaving like the cells of a young person due to aging. While eating chopped up garlic may clear fatty acids build up, the cell dysfunction is a much larger problem that continues unaddressed and their medications do not address this understanding. To compare the cells of a young person who has no pathology with the cells of an old person is of a lower performance in every measure. Fatty acid build up, leaky blood brain barrier, hearing, sight and so on every comparison in every way says that the old person is not performing as well as the young person. While the insight is useful at identifying key declines, reducing medicating for cholesterol does not address the higher cause of cell biology of age. +The difference being male or female is said to be the instructions within the XX chromosome or the XY chromosome. The male produces both types, when the specific gene is read the instruction is a boy or a girl. Some reptiles have an environmental determinate,​ for example hot outside, a male versus cold outside, a female. This illustrates epigenetics and the powerful machine of genetics. One theory of aging is that as part of the complex machinery of evolution, the genetics is programmed ultimately to end life. At a certain age the body down regulates factors that cause the human body to decline and ultimately die. It is also believed that their is a hard genetic cut off switch ending life. Centenarians run in families (genetic cause) and some say that the genetics of the mitochondria in centenarians differs from that of a short-lived person. Progeria is an extremely rare autosomal dominant genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Progeria is one of several progeroid syndromes. Those born with progeria typically live to their mid-teens to early twenties. Progeria is caused by mutations that weaken the structure of the cell nucleus, making normal cell division difficult. The histone mark H4K20me3 is involved in Hutchinson-Gilford Progeria syndrome caused by de novo mutations that occurs in a gene that encodes lamin A. Lamin A is made but is not processed properly. This poor processing creates an abnormal nuclear morphology and disorganized heterochromatin. Patients also do not have appropriate DNA repair, and they also have increased genomic instability. Genetics is so complex that the result is hundreds if not thousands of years of well intended snake oils and years wasted on therapies of limited or inadequate success, possibly a complex situation where a result is impossible and unobtainable. Progeria is a key insight in both genetic errors and cell deformation causing health problems, suggesting that both theories of aging may be correct. Is a hormone or protein later in age produced in correct quantity but perhaps cannot exit the subtle deformity of an aged cell? The difference between a nutrient entering the cell or not is so small that perhaps the aged cell struggles to accept nutrients through its slightly deformed pores and so on. Inbreeding expressing defects in the genome that present as pathology in the body, the likelihood of health issues and early death is increased. Birth defects and DNA damage cell damage relating to nuclear radiation. See how visually the shape of nucleus tells of a problem, that is to consider in cell biology, the slender shapes, the good formations, we are talking about micron deformation here. The cell has to be perfect. These are pathologies that look like aging. When doctors talk of fatty acid build up or some other situation what they are really saying is your cells are aging, and they are not behaving like the cells of a young person due to aging. While eating chopped up garlic may clear fatty acids build up, the cell dysfunction is a much larger problem that continues unaddressed and their medications do not address this understanding. To compare the cells of a young person who has no pathology with the cells of an old person is of a lower performance in every measure. Fatty acid build up, leaky blood brain barrier, hearing, sight and so on every comparison in every way says that the old person is not performing as well as the young person. While the insight is useful at identifying key declines, reducing medicating for cholesterol does not address the higher cause of cell biology of age. Articles: [[removing_wrinkles_inside_our_cells_might_reverse_aging|1]],​ [[neuroscientists_discover_anti_aging_molecule_repairs_age_related_dna_damage|2]]
  
 The Horvath age estimation algorithm (2013), found 353 epigenetic bio markers of human aging, according to which the chronological age of a person was determined with an accuracy of 1.5 years, death date can be predicted to an accuracy of 1.5 years and these bio markers can change depending on epigenetic behaviours like fasting or exercising so a practice can be investigated to be beneficial or not by its effect on the bio markers. The Horvath age estimation algorithm predicts DNAm age based on the methylation levels of 353 CpGs. DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including genomic imprinting, X-chromosome inactivation,​ repression of transposable elements, aging, and carcinogenesis. Correlation or causation? In a study at Kings College London using groups of identical twins, researchers found 490 age related epigenetic changes that could be used as a guide to the stages of biological ageing. Their are other biomarker systems to test efficacy of proposed experimental treatment. The Horvath age estimation algorithm (2013), found 353 epigenetic bio markers of human aging, according to which the chronological age of a person was determined with an accuracy of 1.5 years, death date can be predicted to an accuracy of 1.5 years and these bio markers can change depending on epigenetic behaviours like fasting or exercising so a practice can be investigated to be beneficial or not by its effect on the bio markers. The Horvath age estimation algorithm predicts DNAm age based on the methylation levels of 353 CpGs. DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including genomic imprinting, X-chromosome inactivation,​ repression of transposable elements, aging, and carcinogenesis. Correlation or causation? In a study at Kings College London using groups of identical twins, researchers found 490 age related epigenetic changes that could be used as a guide to the stages of biological ageing. Their are other biomarker systems to test efficacy of proposed experimental treatment.
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 We always hear about the immune system but the body also has a regenerative system, when a person cuts themselves it heals. Focusing in on this system and making it more capable and more powerful. Their is also stem cell therapies where either pluripotent young cells are injected into person, and they lend their factors (growth factors) to the body causing healing or rejuvenation. Such as mesenchymal stem cells. The cells do not have matching DNA, so they are rejected by the immune system but their is an attempt to have them lend their growth factors to existing cells to have them heal faster and run better before the immune system eats them, this therapy might be more effective if the MSC were edited to have matching DNA and matching mitochondria DNA with the patient. This field of stem cells has an very evil temptation and that is using aborted babies as the ideal stem cells for therapies. In some places abortion laws have been quietly altered to facilitate the harvesting of aborted babies. These are not Embryonic Stem Cells nor are they Umbilical cord cells or blood instead Fetal Stem cells, the remains of aborted babies and their are some ugly people that want to absorb them. However, fetal remains are not particularly necessary as their are several other ways to obtain stem cells. Stem cell technology is not ready yet. [[https://​www.thefreelibrary.com/​Do+liver+stem+cells+come+from+bone+marrow%3f-a063692734|Do liver stem cells come from bone marrow]] We always hear about the immune system but the body also has a regenerative system, when a person cuts themselves it heals. Focusing in on this system and making it more capable and more powerful. Their is also stem cell therapies where either pluripotent young cells are injected into person, and they lend their factors (growth factors) to the body causing healing or rejuvenation. Such as mesenchymal stem cells. The cells do not have matching DNA, so they are rejected by the immune system but their is an attempt to have them lend their growth factors to existing cells to have them heal faster and run better before the immune system eats them, this therapy might be more effective if the MSC were edited to have matching DNA and matching mitochondria DNA with the patient. This field of stem cells has an very evil temptation and that is using aborted babies as the ideal stem cells for therapies. In some places abortion laws have been quietly altered to facilitate the harvesting of aborted babies. These are not Embryonic Stem Cells nor are they Umbilical cord cells or blood instead Fetal Stem cells, the remains of aborted babies and their are some ugly people that want to absorb them. However, fetal remains are not particularly necessary as their are several other ways to obtain stem cells. Stem cell technology is not ready yet. [[https://​www.thefreelibrary.com/​Do+liver+stem+cells+come+from+bone+marrow%3f-a063692734|Do liver stem cells come from bone marrow]]
 +
 +Exosomes or mesenchymal stem cells or both? Exosomes from healthy cells carry much of the regenerative proteins of the Mesenchymal Stem Cell and the Exosomes fit the definition of Nan Particles. As Nano particles Exosomes are very small and can penetrate the Blood Brain Barrier. It is believed that much or all of the positive outcomes believed to have been attributed to Mesenchymal Stem Cells for the treatment of neurogenerative disorders are due to the Exosomes from the Mesenchymal Stem Cells. Many scientists now believe that you are skipping right to the Regeneration process by using Exosomes as opposed to Mesenchymal Stem Cell’s while avoiding, or at the very least, mitigating the risk of rejection and problems associated with inflammation.
 +
 +Exosomes deliver micro RNA's systemically,​ they could be engineered to transport therapeutics,​ factors or Yamanka factors.
  
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 The mice that drank the most quickly died. But the mice that drank a limited dose did not develop tumors. Instead, they became more physically robust, their kidneys and spleens worked better, and their hearts pumped harder. In all, the treated mice lived 30% longer than their littermates. The mice that drank the most quickly died. But the mice that drank a limited dose did not develop tumors. Instead, they became more physically robust, their kidneys and spleens worked better, and their hearts pumped harder. In all, the treated mice lived 30% longer than their littermates.
  
-A Stanford team described a feasible way to deliver Yamanaka factors to cells taken from patients, by dosing cells kept in cultures with small amounts of the factors. If dosed for a short enough time, the team reported, the cells retained their identity but returned to a youthful state, as judged by several measures of cell vigor. A Stanford team extracted aged cartilage cells from patients with osteoarthritis and found that after a low dosage of Yamanaka factors the cells no longer secreted the inflammatory factors that provoke the disease. The team also found that human muscle stem cells, which are impaired in a muscle-wasting disease, could be restored to youth. Members of the Stanford team have formed a company, Turn Biotechnologies,​ to develop therapies for osteoarthritis and other diseases. Another company is AgeX and GenuCure developing various treatments heart tissues, osteoarthritis,​ aging-related muscle loss, rejuvenating cartilage.+A Stanford team described a feasible way to deliver Yamanaka factors to cells taken from patients, by dosing cells kept in cultures with small amounts of the factors. If dosed for a short enough time, the team reported, the cells retained their identity but returned to a youthful state, as judged by several measures of cell vigor. A Stanford team extracted aged cartilage cells from patients with osteoarthritis and found that after a low dosage of Yamanaka factors the cells no longer secreted the inflammatory factors that provoke the disease. The team also found that human muscle stem cells, which are impaired in a muscle-wasting disease, could be restored to youth. Members of the Stanford team have formed a company, Turn Biotechnologies,​ to develop therapies for osteoarthritis and other diseases. Another company is AgeX and GenuCure developing various treatments heart tissues, osteoarthritis,​ aging-related muscle loss, rejuvenating cartilage. ​[[old_human_cells_rejuvenated_stem_cell_technology|1]]
  
 Other scientists are experimenting with the factors, by leaving some out or another derivative cell quality improves and cancer is less probable.  ​ Other scientists are experimenting with the factors, by leaving some out or another derivative cell quality improves and cancer is less probable.  ​
regenetive_medicine_anti_aging_immortality.1590246518.txt.gz · Last modified: 2020/05/23 15:08 by admin